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. 2015 Aug 3;6:395. doi: 10.3389/fimmu.2015.00395

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Copyright © 2015 Caramalho, Nunes-Cabaço, Foxall and Sousa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of human Treg development in the human thymus. DP, double-positive (CD4⁺CD8⁺); CD4SP, CD4 single-positive (CD4⁺CD8^neg); CD8SP, CD8 single-positive (CD8⁺CD4^neg); cTEC, cortical thymic epithelial cell; mTEC, medullary TEC; Mac, macrophage; FOXP3, Forkhead box P3; TSLP, thymic stromal lymphopoietin.