Figure 4.

Exemplary, a schematic overview of the central metabolism of C. glutamicum including carboxylases and TPP-dependant decarboxylases. Abbreviations: ACC, acetyl-CoA carboxylase; AHAIR, acetohydroxyacid isomeroreductase; AHAS, acetohydroxyacid synthase; AK, acetate kinase; AlaT, alanine aminotransferase; AvtA, valine-pyruvate aminotransferase; CA, carbonic anhydrase; DHAD, dihydroxyacid dehydratase; GDH, glutamate dehydrogenase; GPDH, glucose-6P dehydrogenase; ICD, isocitrate dehydrogenase; MalE, malic enzyme; ODHC, 2-ketoglutarate dehydrogenase complex; ODx, oxaloacetate decarboxylase; PCx, pyruvate carboxylase; PDHC, pyruvate dehydrogenase complex; PEP phosphoenolpyruvate; PEPCk, PEP carboxykinase; PEPCx, PEP carboxylase; PGDH, 6P-gluconate dehydrogenase; PK, pyruvate kinase; PQO, pyruvate:quinone oxidoreductase; PTA, phosphotransacetylase; TA, transaminase B; TPP, thiamine pyrophosphate.