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. Author manuscript; available in PMC: 2015 Aug 3.
Published in final edited form as: Lancet Oncol. 2013 Jul;14(8):e321–e328. doi: 10.1016/S1470-2045(13)70107-4

Table 1.

Inclusion and Exclusion Criteria for the 3 Key Questions*

Variable Question 1 Question 2 Question 3
Inclusion criteria
 Population
  Cancer survivors who received a diagnosis of brain tumor after cranial radiation X X X
  Previous diagnosis of cancer as a child or young adult X X X
 Study design
  Retrospective cohort X X X
  Retrospective case:control X X X
  Prospective cohort or clinical trial X
 Outcomes
  Risk estimates of subsequent brain tumors: standardized incidence ratios, relative risks, absolute excess risks or cumulative incidence; overall and treatment-based (radiation) risk estimates X
  Clinical characteristics of subsequent brain tumor: location, pathologic features, interval since primary cancer X
  Progression-free and overall survival X
Exclusion criteria
 Study did not include humans X X X
 Study was not published in English X X X
 Case report, review, editorial, or letter X X X
*

Question 1: What is the risk of subsequent CNS tumors following radiation to the cranium for a pediatric cancer? Question 2: What are the outcomes in children with subsequent neoplasms of the CNS who have been treated with cranial radiation for a pediatric cancer? Question 3: Are outcomes of subsequent neoplasms different from primary neoplasms of the same histology?