Table 1.
Variable | Question 1 | Question 2 | Question 3 |
---|---|---|---|
Inclusion criteria | |||
Population | |||
Cancer survivors who received a diagnosis of brain tumor after cranial radiation | X | X | X |
Previous diagnosis of cancer as a child or young adult | X | X | X |
Study design | |||
Retrospective cohort | X | X | X |
Retrospective case:control | X | X | X |
Prospective cohort or clinical trial | X | ||
Outcomes | |||
Risk estimates of subsequent brain tumors: standardized incidence ratios, relative risks, absolute excess risks or cumulative incidence; overall and treatment-based (radiation) risk estimates | X | ||
Clinical characteristics of subsequent brain tumor: location, pathologic features, interval since primary cancer | X | ||
Progression-free and overall survival | X | ||
Exclusion criteria | |||
Study did not include humans | X | X | X |
Study was not published in English | X | X | X |
Case report, review, editorial, or letter | X | X | X |
Question 1: What is the risk of subsequent CNS tumors following radiation to the cranium for a pediatric cancer? Question 2: What are the outcomes in children with subsequent neoplasms of the CNS who have been treated with cranial radiation for a pediatric cancer? Question 3: Are outcomes of subsequent neoplasms different from primary neoplasms of the same histology?