Year of Publication |
2012 |
2006 |
1998 |
2009/2010 |
2010 |
Patients with High-Grade Gliomas |
2227 |
18 |
10 |
73 |
40 |
STROBE Criteria(17) met, n/n |
N/A |
19/30 |
25/30 |
30/33 |
31/32 |
Study design |
N/A |
Cohort |
Cohort |
Population-based Cohort |
Cohort |
Median age at first cancer diagnosis (range) |
--- |
4·25 years (0·1 – 9 years) |
2·5 years (1·9 – 15·3 years) |
n/a |
n/a |
Exposure to cranial radiation, % |
--- |
18 (100%) |
10 (100%) |
n/a |
38 (95%) |
Median interval to subsequent high-grade gliomas (range) |
--- |
8 years (6 – 14 years) |
9·1 years |
20 years (mean) |
9 years |
Median age at diagnosis of subsequent high-grade gliomas (range) |
20 – 44 years |
14 years (7 – 19 years) |
9·4 years (7·6 – 13·2 years) |
n/a |
15 years |
Survival of patients with high-grade gliomas, % |
N/A |
1 (6%) |
1 (10%) |
11 (15%) |
n/a |
5 year survival rate |
16·6% |
0% |
10% |
19·5% (95% CI: 9·8% – 33·7%) |
n/a |