Table 3.

Outcomes of Subsequent High-Grade Gliomas among Childhood Cancer Survivors

Characteristic	General Population	Childhood Cancer Survivors with Subsequent Gliomas
Study	Central Brain Tumor Registry of the United States (CBTRUS) 2012 Statistical Report	Carret AS Radiotherapy and Oncology 2006;81:33–38(34)	Walter AW Journal of Clinical Oncology 1998;16:3761–3767(35)	Taylor AJ Journal of Clinical Oncology 2009; 27:5781–5787(13)	Neglia JP J Natl Cancer Inst 2006;98:1528 – 37(7)
Year of Publication	2012	2006	1998	2009/2010	2010
Patients with High-Grade Gliomas	2227	18	10	73	40
STROBE Criteria(17) met, n/n	N/A	19/30	25/30	30/33	31/32
Study design	N/A	Cohort	Cohort	Population-based Cohort	Cohort
Median age at first cancer diagnosis (range)	---	4·25 years (0·1 – 9 years)	2·5 years (1·9 – 15·3 years)	n/a	n/a
Exposure to cranial radiation, %	---	18 (100%)	10 (100%)	n/a	38 (95%)
Median interval to subsequent high-grade gliomas (range)	---	8 years (6 – 14 years)	9·1 years	20 years (mean)	9 years
Median age at diagnosis of subsequent high-grade gliomas (range)	20 – 44 years	14 years (7 – 19 years)	9·4 years (7·6 – 13·2 years)	n/a	15 years
Survival of patients with high-grade gliomas, %	N/A	1 (6%)	1 (10%)	11 (15%)	n/a
5 year survival rate	16·6%	0%	10%	19·5% (95% CI: 9·8% – 33·7%)	n/a