Table 3.
Logistic regression models for BPD (3a) and severe BPD (3b) in our cohort:
| Variable | Odds ratio | 95% CI | P - value |
|---|---|---|---|
| BPD | |||
| GA ≤ 26wk | 3.4 | 2.1 – 5.7 | <.0001 |
| Birth weight ≤ 800g | 2.5 | 1.4 – 4.2 | 0.001 |
| Male | 1.5 | 1.04 – 2.2 | 0.03 |
| NFE2L2 CA or AA vs. CC | 0.6 | 0.4 – 0.9 | 0.023 |
| AA vs. CAU | 0.3 | 0.2 – 0.5 | <.0001 |
| NQO1 TT vs. CC or CT | 3.0 | 1.4 – 6.8 | 0.007 |
| PDA | 3.1 | 2.1 – 4.5 | <.0001 |
| Severe BPD | |||
| GA ≤ 26wk | 3.8 | 2.1 – 6.7 | <.0001 |
| Birth weight ≤ 800g | 2.5 | 1.4 – 4.5 | 0.002 |
| Male | 2.0 | 1.3 – 3.1 | 0.003 |
| NFE2L2 CA or AA vs. CC | 0.3 | 0.2 – 0.6 | 0.0004 |
| AA vs. CAU | 0.5 | 0.3 – 0.9 | 0.02 |
| NQO1 TT vs. CC or CT | 2.5 | 1.01 – 6.0 | 0.049 |
| PDA | 2.3 | 1.5 – 3.7 | 0.0003 |
Epidemiological variables available at birth, ARE variants, and postnatal variable (PDA) were investigated with logistic regression to model BPD and severe BPD risk (see full description in methods section). The final model representing significant factors (p<0.05) associated with BPD and severe BPD are depicted.