Table 1. Summary of corin findings.
Corin | References | |
---|---|---|
Type | Transmembrane serine protease | 9 |
Role | Process proBNP1-108 and proANP1-126 | 2 |
Existence in Human | Heart and kidney | 9,12,49, |
Knockout mice | HT and LVH | 57 |
Animal model | ||
Heart Failure | Rat mRNA (atrium) - decrease | 53 |
Rat mRNA (ventricle)- increase | 56 | |
Myocardial Infarction | Rat mRNA (ventricle) - increase | 54, 55 |
Human SNPs | HT and LVH, impaired BNP processing | 58-61 |
Human disease state | ||
Heart Failure | decrease (plasma) | 63,64 |
increase (ventricle) | 72 | |
Valvular Disease | no change (aortic valve) | 73 |
SNPs, single nucleotide polymorphisms; BNP, b-type natriuretic peptide; ANP, atrial natriuretic peptide; HT, hypertension; LVH, left ventricular hypertrophy.