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. Author manuscript; available in PMC: 2015 Aug 3.
Published in final edited form as: Adv Clin Chem. 2013;61:1–31. doi: 10.1016/b978-0-12-407680-8.00001-4

Table 1. Summary of corin findings.

Corin References
Type Transmembrane serine protease 9
Role Process proBNP1-108 and proANP1-126 2
Existence in Human Heart and kidney 9,12,49,
Knockout mice HT and LVH 57
Animal model
Heart Failure Rat mRNA (atrium) - decrease 53
Rat mRNA (ventricle)- increase 56
Myocardial Infarction Rat mRNA (ventricle) - increase 54, 55
Human SNPs HT and LVH, impaired BNP processing 58-61
Human disease state
Heart Failure decrease (plasma) 63,64
increase (ventricle) 72
Valvular Disease no change (aortic valve) 73

SNPs, single nucleotide polymorphisms; BNP, b-type natriuretic peptide; ANP, atrial natriuretic peptide; HT, hypertension; LVH, left ventricular hypertrophy.