Table 2.
Baseline characteristics of subjects with and without readmissions
| Subjects without a readmission (n=216) | Subjects readmitted only to the ward (n=201) | p1 | Subjects with at least one ICU readmission (n=95) | p2 | |
|---|---|---|---|---|---|
| Birth weight, g, mean (SD) | 827.8 (182.3) | 812.6 (187.1) | 0.16 | 801.9 (192.2) | 0.16 |
| Birth weight, g, median (IQR) | 807.5 (687.0–941.0) | 780.0 (680.0–915.0) | 743.0 (673.0–922.0) | ||
| Birth weight strata, n (%) | 0.06 | 0.04 | |||
| 500–749 g | 78 (36.1) | 88 (43.8) | 49 (51.6) | ||
| 750–999 g | 97 (44.9) | 75 (37.3) | 31 (32.6) | ||
| 1000–1250 g | 41 (19.0) | 38 (18.9) | 15 (15.8) | ||
| Gestational age, weeks, mean (SD) | 26.0 (1.8) | 26.0 (1.9) | 0.65 | 25.7 (1.7) | 0.24 |
| Gestational age, weeks, median (IQR) | 26.0 (25.0–27.0) | 26.0 (25.0–27.0) | 25.0 (24.0–27.0) | ||
| Sex, n (%) | 0.01 | 0.001 | |||
| Female | 124 (57.4) | 101 (50.3) | 35 (36.8) | ||
| Male | 92 (42.6) | 100 (49.7) | 60 (63.2) | ||
| Race/Ethnicity, n (%) | 0.53 | 0.26 | |||
| African-American | 42 (19.4) | 48 (23.9) | 17 (17.9) | ||
| Caucasian | 139 (64.4) | 127 (63.1) | 68 (71.6) | ||
| Hispanic | 29 (13.4) | 22 (11.0) | 6 (6.3) | ||
| Asian / Other | 6 (2.8) | 4 (2.0) | 4 (4.2) | ||
| Apgar score at 1 minute, median (IQR) | 4.0 (2.0–6.0) | 4.0 (2.0–6.0) | 0.82 | 4.5 (2.0–6.0) | 0.69 |
| Apgar score at 5 minutes, median (IQR) | 7.0 (5.0–8.0) | 7.0 (6.0–8.0) | 0.82 | 7.0 (5.0–8.0) | 0.94 |
| Baseline OI, mean (SD) | 4.8 (3.6) | 5.0 (4.1) | 0.95 | 5.6 (6.7) | 0.85 |
| Baseline OI, median (IQR) | 3.9 (2.7–5.6) | 3.8 (2.7–5.5) | 3.9 (2.8–5.5) | ||
| Baseline ICH, n (%) | 0.83 | 0.37 | |||
| Grades 1–2 | 35 (16.4) | 33 (16.5) | 19 (20.4) | ||
| Grades 3–4 | 10 (4.7) | 9 (4.5) | 7 (7.5) | ||
| SGA, n (%) | 0.23 | 0.66 | |||
| SGA | 11 (5.1) | 17 (8.5) | 6 (6.3) | ||
| Not SGA | 205 (94.9) | 184 (91.5) | 89 (93.7) | ||
| Surfactant, n (%) | 0.99 | 0.83 | |||
| Received surfactant | 175 (81.0) | 164 (81.6) | 76 (80.0) | ||
| Did not receive surfactant | 41 (19.0) | 37 (18.4) | 19 (20.0) | ||
| Treatment group, n (%) | 0.55 | 0.71 | |||
| iNO | 111 (51.4) | 109 (54.2) | 51 (53.7) | ||
| Placebo | 105 (48.6) | 92 (45.8) | 44 (46.3) | ||
| Treatment group by weight strata, n (%) | |||||
| 500–749 g | 0.62 | 0.67 | |||
| iNO | 40 (51.3) | 48 (54.5) | 27 (55.1) | ||
| Placebo | 38 (48.7) | 40 (45.5) | 22 (44.9) | ||
| 750–999 g | 0.25 | 0.41 | |||
| iNO | 48 (49.5) | 43 (57.3) | 18 (58.1) | ||
| Placebo | 49 (50.5) | 32 (42.7) | 13 (41.9) | ||
| 1000–1250 g | 0.30 | 0.29 | |||
| iNO | 23 (56.1) | 18 (47.4) | 6 (40.0) | ||
| Placebo | 18 (43.9) | 20 (52.6) | 9 (60.0) |
iNO – subjects treated with inhaled nitric oxide; SGA – small for gestational age; SD – standard deviation; g – grams; IQR – interquartile range; OI – oxygenation index; ICH – intracranial hemorrhage
p1 values are for comparison between subjects without a readmission vs. subjects with any readmission (with or without ICU stay)
p2 values are for comparison between subjects without a readmission vs. subjects with an ICU readmission