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. 2015 Aug 15;32(16):1210–1216. doi: 10.1089/neu.2014.3771

Table 1.

Time Schedule of TBI Induction, Dosing, ICP/PbtO2/CPP Measurement, and Imaging after Craniectomy in Each Group (n=5 per Group)

  Time (h) after completing craniectomy
  0h 24h 25h 47h-49h 167h-169h
Group 1 Craniectomy   Vehicle ICP/pbtO2/CPP  
Group 2 Craniectomy   E2-SO4 ICP/pbtO2/CPP  
Group 3 Craniectomy TBI Vehicle ICP/pbtO2/CPP  
Group 4 Craniectomy TBI E2-SO4 ICP/pbtO2/CPP  
Group 5 Craniectomy   Vehicle or E2-SO4 DTI/PET/CT DTI/PET/CT
Group 6 Craniectomy TBI Vehicle DTI/PET/CT DTI/PET/CT
Group 7 Craniectomy TBI E2-SO4 DTI/PET/CT DTI/PET/CT

TBI, traumatic brain injury; ICP, intracranial pressure; PbtO2, brain partial oxygen pressure; CPP, cerebral perfusion pressure; E2-SO4, estrogen sulfate; DTI, diffusion tensor imaging; PET, positron emission tomography.