Figure 3.

Top networks associated with mouse (host) genes induced by metronomic CPA treatment, as determined by IPA. A) Top network showing connections between metronomic CPA-induced expression of innate immunological disease (many macrophage-related), adhesion, infiltration, scavenger, and cytolysis genes. B) Top networks for NK cell-related innate immune function: tumoricidal and infectious disease NK function, targeting via CXCR3 and FAS, and cytolysis via granzyme and perforin, and C), NK cell-related inflammatory disease network. Deeper shades of red indicate stronger up regulation of the gene by metronomic CPA treatment. Solid arrows: protein-DNA interactions; solid lines: protein-protein; dashed arrows: regulation of gene expression; colored: related to highlighted factor(s). Shapes indicate protein family: rectangle: receptor; square: cytokine; triangle: kinase; diamond: enzyme; oval: factor (i.e., transcription); concentric circles: complex; circle: other.