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. 2015 Aug 1;34(8):505–510. doi: 10.1089/dna.2015.2896

FIG. 2.

FIG. 2.

Structure of the RSV F protein. (A) Crystal structures of RSV F in the prefusion (PDB ID:4MMQ) and postfusion (PDB ID: 4RRR) conformations. Pan-resistance hot spots D401 (magenta) and D489 (pink) and residue Y198 (blue) identified in covalent inhibitor cross-linking studies are highlighted. F domains are color-coded as in Figure 1A. (B) Cocrystal structures of synthetic RSV F 6HB [boxed out region in (A)] and TMC-353121 (yellow) (PDB ID: 3KPE). The close-up shows TMC-353121 filling the hydrophobic HR-A pocket typically occupied by HR-B residues 486 and 487. 6HB coloring is based on hydrophobicity, red being most hydrophobic. Selected surrounding HR-A and HR-B residues are labeled.