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. 2015 Aug 15;32(16):1190–1199. doi: 10.1089/neu.2014.3669

FIG. 3.

FIG. 3.

Quantification of messenger ribonucleic acid (mRNA) levels of the biosynthetic enzymes tryptophan hydroxylase 2 (TPH2) in the dorsal raphe nucleus (DRN; A-B) and of tyrosine hydroxylase (TH) in the locus coeruleus (LC; C-D), at 2 h, 1 d, 3d, and 7 d post-exposure in the rat. The expression levels of the mRNA at each time-point were normalized to sham levels (shams of the different time-points showed no statistical difference and were pooled). There is an initial increase in TPH2 mRNA levels immediately post-exposure, which lasts up to 1 d, and is statistically significant in the mid/caudal part of the DRN (A). An increase in TH mRNA in both the right LC (C) and left (D) is detected as early as 2 h post-exposure continuing to rise up to 3d and returning to sham levels at 7d. Data are presented as mean±standard error of the mean. *p<0.05, **p<0.01, ***p<0.001.