FIG. 2.

Weight loss, amelioration of heart-aorta weight, and aorta dilation. Mice with accelerated atherosclerosis (Ang II/Sal & Ang II/GGE) showed significant weight loss compared to control mice (A). The weight of the heart vessels and aorta was significantly increased in the Ang II/Sal compared to both the control and Ang II/GGE groups (B). The BW ratio was obtained by dividing the body weights on day 0 and the weight on each subsequent day. The external morphology of the aorta of Ang II/Sal mice showed aneurism-like dilation compared to other two groups of mice (C). The aorta showed a significant increased area in the aorta from Ang II/GGE mice compared to Sal/Sal and Ang II/GGE groups. Bars indicate the mean±SEM. Scale bars indicate 2 mm. Statistical analysis was performed by ANOVA with post hoc analysis using Fisher's predicted least significant difference test. Ang II, angiotensin II; Sal, saline. *p<0.05, compared to Ang II/Sal and Ang II/GGE groups. Color images available online at www.liebertpub.com/jmf