Table 3.
Oxidative Stress Biomarkers in Joint Tissue and Serum of Specimens with Chronic Inflammation Treated with Spirulina maxima (n=8)
| Serum | Joint tissue | ||||
|---|---|---|---|---|---|
| Treatment | Day | PCC (nmol carbonyl/mL) | LPO (nmol MDA/mL) | PCC (μmol carbonyl/g) | LPO (μmol MDA/g) |
| Negative control (PBS) | 0 | 202.47±22.49 | 35.14±3.64 | ||
| 28 | 172.83±25.30 | 25.97±3.17 | 1.09±0.19 | 0.68±0.15 | |
| Positive control (CFA) | 0 | 259.70±11.35 | 32.05±0.69 | ||
| 28 | 706.18±71.52a• | 57.97±6.52a• | 7.53±0.96a | 2.07±0.26a | |
| PB 100 mg/kg | 0 | 288.55±17.60 | 21.78±1.69 | ||
| 28 | 162.78±5• | 15.84±0.85 | 1.19±0.03 | 0.48±0.01 | |
| SP 800 mg/kg | 0 | 127.66±30.60 | 10.47±1.42 | ||
| 28 | 124.90±2 | 11.33±1.73 | 0.53±0.05a | 0.24±0.004a | |
| CFA+PB 100 mg/kg | 0 | 297.71±11.43 | 24.69±13.32 | ||
| 28 | 392.61±41.66ab• | 19.33±0.94b | 2.63±0.25ab | 2.86±1.07a | |
| CFA+SP 800 mg/kg | 0 | 384.03±53.95 | 29.39±4.68 | ||
| 28 | 274.84±11.91abc• | 34.75±3.37b | 2.39±0.16ab | 0.5±0.06bc | |
Values are the mean±SE. Two-way repeated measures ANOVA (serum) and ANOVA on ranks (joint tissue), SNK post hoc test (P<.05).
a
Versus negative control.
b
Versus positive control.
c
Versus CFA+PB.
•
Versus d0.
PCC, protein carbonyl content; LPO, lipid peroxidation.