Table 6.
Results of Studies Evaluating the Outcome of Pituitary CRT in Patients With CD
| First Author, Year (Ref.) | No. of Patients | Follow-Up, mo | Dose, Gy | Remission Rate, % | Time to Remission, mo | Recurrence Rate, % | Time to Recurrence, mo | Tumor Control Rate, % | Hypopituitarism, % | Optic Nerve Damage, % |
|---|---|---|---|---|---|---|---|---|---|---|
| Orth, 1971 (298)* | 51 | R:12–168 M:108 |
45 | 19.6 | NA | NA | NA | NA | 0 | 0 |
| Edmonds, 1972 (299)* | 15 | R:48–120 | R:35–50 | 60 | R:1–6 | 11.1 | M:18 | NA | NA | NA |
| Ross, 1979 (300)* | 13 | M:48 | 46 | 61.5 | NA | 62.5 | NA | NA | NA | NA |
| Ahmed, 1984 (301)* | 19 | R:12–96 M:43.2 |
20 | 36.8 | R:6–12 | 0 | na | NA | 0 | NA |
| Sharpe, 1985 (302)* | 8 | R:60–144 M:108 |
43 | 100 | NA | 12.5 | M:120 | NA | 100 | NA |
| Howlett, 1989 (303) | 30 (21,* 9) | R:69.6–186 M:123.6,* m:114* M:52.2 m:36.2 |
45 | 57.1,* 55.6 | NA | 0 | na | 100,* 100 | 28.6,* NA | 0 |
| Littley, 1990 (304)* | 24 | R:13–171 M:99.4 m:93 |
20 | 45.8 | R:4–36 M:15.9 m:16 |
45.4 | R:18–63 M:50.7 m:50.6 |
NA | 66.7 | 0 |
| Vicente, 1991 (305) | 10 | R:18–42 M:29.1 m:27 |
50 | 80 | R:12–36 | 0 | na | NA | 30 | NA |
| Tran 1991 (306) | 3 (2,* 1) | R:30–250 M:84 |
49 | 100 | NA | NA | NA | NA | 77.7** | 0 |
| Murayama, 1992 (307)* | 20 | R:24–300 M:148.8 m:114 |
54 | 80 | R:2–28 M:10.2 m:6.5 |
25 | R:60–84 M:5.7 m:5.5 |
100 | 30 | 0 |
| Zierhut, 1995 (308) | 7 | R:12–216 M:84 |
45 | 57.1 | R:16–104 | 5.3** | R:9–98** M:34.8** |
94.1** | 58.5** | 1.4** |
| Sonino, 1996 (159) | 42 (19,* 23) | R:24–216 m:120 |
R:45–50 | 73.7,* 39.1 | NA | 50,* 0 | NA | NA | NA | NA |
| Tsang, 1996 (309) | 29 (8,* 3, 18***) | R:1–223 m:87.6 |
R:40–52 | 55.2 | NA | NA | NA | 96*** | 13.9–31.1** | 0 |
| Estrada, 1997 (310) | 30 | R:18–114 M:55 m:42 |
50 | 83.3 | M:18 | 0 | na | 100 | 23.3 | 0 |
| Minniti, 2007 (311) | 40 | R:24–180 m:108 |
44 | 80 | M:24 | 0 | na | 92.5 | 74.9 | 0 |
| Total | 341 |
R:1–300 M:81.9 m:86.2 |
R:20–54 M:43.5 m:45 |
R:19.6–100 M:63.8 m:60 |
R:1–104 M:17.4 m:6.5 |
R:0–62.5 M:15.9 m:0 |
R:18–84 M:48.6 m:28.1 |
R:53–100 M:98.5 m:100 |
R:0–100 M:39.3 m:30 |
0 |
Abbreviations: NA, not available; na, not applicable; R, range, M, mean; m, median. This table lists the studies addressing the outcome of pituitary CRT that were published between 1971 and 2007, including those whose entire content was fully available for the authors. The last line (total) includes the general range and the “average” mean and median values of the different parameters included in the studies, considering exclusively those where these parameters were available and were clearly attributable to the only patients with CD.
Primary therapy without surgery.
These data are related to a population including all types of pituitary tumors.
Radiation therapy as part of a salvage therapy.