Table I.

Summary of MMOA Testing

Substance ID (Pubchem)	EC50 for LAMP inhibition (μM)1	Inhibition of LAMP signal (%)2	Inhibition of BLT esterase Release (%)2	Inhibition of Fura-2 signal (%)3	Inhibition of MAPKK phosphorylation (%)4	Inhibition of calcineurin activity (%)5	Inhibition of Cdc25C phosphorylation (%)6
Calcium Inhibitors
24817911	3.4%	101	91	59
22417005	6.0%	100	95	78
51090459	6.0/M	100	91	69
17408817	1.1M	100	90	63
92764822	3.2%	100	81	67
49673940	4.5%	100	96	91
92764425	0.5M	99	88	57
49721823	0.3%	99	97	76
4246714	2.3%	99	94	116
49714966	4.0%	99	88	79
99495188	2.1%	98	86	70
51089860	0.6M	98	67	51
26728166	1.8M	73	63	91
26728904	3.2M	70	68	80
99456627	5.0M	56	68	81
MAPKK Inhibitors
3713060	2.5%	100	99		84
248109231	1.4%	99	80		79
124755744	4.0%	95	76		51
26727153	3.7%	95	92		66
56324549	1.1%	95	55		87
17414945	0.3%	89	72		67
99359838	1.4M	78	61		53
Calcineurin Inhibitors
92764285	1.5%	100	97			100
Inhibitors of more than one pathway
24840307	0.8M	98	83	27	36
124755743	4.9M	94	64	37	37
99359840	1.4M	60	45	20	35		13
124755736	5.0%	95	74	38	28		6
24815073	3.3M	81	51	42	12		14
14737268	1.6%	85	73	18	40		16
7977862	0.8%	93	89	38			17
49665798	4.9%	85	67	40	40
Unknown MMOA
7977862	0.9%	93	89	0	0		17
103159345	5.1M	79	54	0	0		0
103060008	3.5%	83	77	23	0		0
103073958	3.1%	70	63	32	0		0
03075418	3.9%	53	41	11	0		0
103074366	1.8M	53	64	40	0		0
49677461	2.1M	87	52	36	0		0
17387000	2.2M	80	68	0	38		0

All data are the average of at least two separate determinations

¹Obtained from fits to dose-response data. % indicates that the fit was to data analyzed by computing the % positive cells, while M indicates that mean fluorescence intensity was used.

²Defined as in Figure 2.

³From data presented in Figure 3.

⁴From data in Figure 4.

⁵From data in Figure 5.

⁶From data in Figure 6.