Table 2.
Patient | Age (Years) | Etiology | Coil Position | rTMS Intensity | rTMS Frequency | Train Duration | # Trains | Outcome | Adverse Events |
---|---|---|---|---|---|---|---|---|---|
1 [8] | 7 | Unknown, focal cortical atrophy on MRI | Seizure Focus | 50% MO | 20 Hz | 2 sec | 15 | Clinical seizures became intermittent and stopped in 24 hrs | none reported |
2 [8] | 11 | Unknown, focal cortical atrophy on MRI | Seizure Focus | 128% MT | 20 Hz | 2 sec | 15 | No change in clinical seizures, improved EEG | none reported |
3 [11] | 48 | Unknown, Normal MRI | Seizure Focus | 100% MT | 0.5 Hz | 900 sec | 16 (2 trains per session, biweekly, for 4 weeks) | Clinical seizures decreased during rTMS, and decreased further on follow-up | none reported |
4 [9] | 31 | Cortical Dysplasia | Seizure Focus | 90% MT | 0.5 Hz | 200 sec | 1 | Clinical seizures stopped, resumed in 2 months, and stopped again with rTMS | none reported |
5 [10] | 8 | Neuronal ceroid lipofuscinoscis (probable) | Seizure Focus | 100% MO | 6 Hz than 1 Hz | 6 Hz: 5 sec 1Hz: 600 sec | 3 (1 Hz, one preceded by 4 trains at 6 Hz) | No change | none reported |
6 [10] | 16 | Perinatal stroke | Seizure Focus | 76% MO | 6 Hz then 1 Hz | 6 Hz: 5 sec 1Hz: 900 sec | 2 (1 Hz, one preceded by 4 trains at 6 Hz) | No change | mild headache and leg pain |
MO: machine output; MT: motor threshold.