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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Neurobiol Dis. 2014 Dec 3;74:167–179. doi: 10.1016/j.nbd.2014.11.014

Fig. 1.

Fig. 1

EVC-induced IOP elevation leads to a progressive loss of RGCs and their axons, even after the IOP has returned to normal levels. A, Time course of IOP after EVC (n=40/time point). IOP elevation was observed at 1 day and was sustained for 6 weeks after EVC treatment. B, Representative photographs of FG-labeled RGCs in flat-mounted retinas (top panels, scale bar, 100 μm) and toluidine blue staining of optic nerve cross-sections (bottom panels, scale bar, 100 μm). C, D, Quantitation of FG-labeled RGCs (C) and axons in the optic nerve (D) in EVC-treated eyes during IOP elevation and after return of the IOP to normal levels (n=8/time point). The values are the means ± SEMs. *p<0.05 and ** p<0.01 compared with the contralateral sham operation control eye. EVC: episcleral vein cauterization. w: week, mo: month.