Figure 7. Skin grafts of only MHC-mismatched strain were not rejected following Foxp3+ cell depletion.
Morphological changes of skin allografts of DBA/2 (fully mismatched) and B6.C-H2d/bByJ (only MHC-mismatched) before and after diphtheria toxin (DT) treatment. Allograft tolerance was confirmed over 50 days before DT treatment. Shown are representative images among four Group A recipients which were transplanted both DBA/2 and B6.C-H2d/bByJ grafts. All DBA/2 allografts were rejected within 15 days post-DT. All B6.C-H2d/bByJ grafts were accepted for the observational period, over 50 days post-DT.