Table 1. Hepatic lipid content in WT, LKO, DKO, and TKO mice.
Liver lipid concentrations (nmol lipid/mg liver homogenate protein) were determined as described in Methods.
Lipid | WT nmol/mg | LKO nmol/mg | DKO nmol/mg | TKO nmol/mg |
---|---|---|---|---|
Total Lipid | 189±7a | 229±5b | 370±30c | 380±20c |
C | 22±1a | 32±2b | 33±4b | 45±4c |
CE | 20±1a | 28±1b | 61±9c | 53±5c |
NEFA | 28±2a | 19±1b | 90±5c | 93±7c |
PL | 32±1a | 82±4b | 89±6b | 86±7b |
TG | 87±7a | 74±3a | 90±10a | 99±6a |
C, cholesterol; CE, cholesteryl ester; NEFA, nonesterified fatty acid; PL phospholipid; TG, triglyceride. Total lipid concentrations were obtained by adding the individual lipid concentrations. Values = means ± SEM (n = 8). Statistically different values (P < 0.05, ANOVA) within a row (lipid class) are denoted by a different lower-case letter (a, b, c).