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. 2015 Jun 12;172(15):3929–3943. doi: 10.1111/bph.13184

Figure 6.

Figure 6

DMF activates JNK, p38 and ERK MAPKs in CT26 cells. (A) The time course of DMF-induced JNK, p38 and ERK activation in CT26 cells.*P < 0.05, **P < 0.01 versus control. (B) JNK, p38 and ERK inhibitors attenuated DMF-induced cell death in CT26 cells as shown by the CCK8 assay. SP, JNK inhibitor SP600125; SB, p38 inhibitor SB203580; PD, ERK inhibitor PD98059. **P < 0.01 versus control; ##P < 0.01 versus DMF. Cells were pretreated with the JNK inhibitor SP600125, p38 inhibitor SB203580, or ERK inhibitor PD98059 for 1 h, then DMF(100 μM) was added until 24 h.