Table 2. Membrane potential properties during baseline and H2O2.
Properties of THR, RMP, [THR-RMP], rheobase and other parameters of the first AP generated by step depolarization during baseline, H2O2 and wash.
| baseline | H2O2 | wash | n (H2O2/wash) | |
|---|---|---|---|---|
| RMP [mV] | −59.82 ±1.56 | −69.61 ±2.36 * | −57.17 ±1.83 † | 26/23 |
| THR [mV] | −26.09 ±1.03 | −33.35 ±2.15 * | −31.13 ±1.58 * | 23/20 |
| [THR-RMP] [mV] | 33.33 ±1.95 | 35.62 ±1.83 | 25.74 ±1.86 *† | 23/20 |
| Rheobase [pA] | 66.55 ±13.55 | 92.15 ±15.58 * | 38.40 ±6.69 † | 23/19 |
| Overshoot [mV] (over 0 mV) | 35.61 ±1.71 | 25.10 ±3.15 * | 26.60 ±3.21 * | 23/20 |
| AP amplitude from RMP [mV] | 95.03 ±2.20 | 94.07 ±2.72 | 83.47 ±3.61 *† | 23/20 |
| AP amplitude from THR [mV] | 61.70 ±1.64 | 58.45 ±2.25 * | 57.73 ±3.00 | 23/20 |
| Half width [ms] | 1.11 ±0.06 | 1.17 ±0.05 | 1.19 ±0.05 | 19/16 |
| Rising slope [mV/ms] | 195.39 ±11.47 | 178.70 ±13.31 | 158.08 ±13.80 * | 20/17 |
| Falling slope [mV/ms] | −93.16 ±6.05 | −86.64 ±4.53 | −72.49 ±4.21 *† | 20/17 |
| Afterhyperpolarisation from THR [mV] | 19.94 ±3.74 | 18.72 ±4.79 | 15.51 ±4.14 | 23/20 |
One-way RM ANOVA;
compared to baseline,
compared to H2O2; p < 0.05. “n” represents the number of observations during H2O2 and wash.