Table 1.
Summary of experimental findings of altering Maf1 across species.
| Manipulation | Organism | Tissue/ Type | Phenotype | Ref. |
|---|---|---|---|---|
| C. elegans | All mafr-1
expressing tissues |
RNA pol II, III Lipid homeostasis Reproduction |
16 | |
| Overexpression |
|
|||
| RNA pol I, II, III | 23, 38 | |||
| Glioblastoma |
|
|||
| Human cell |
Anchorage independent growth |
38 | ||
|
|
||||
| Liver | Triglyceride levels | 23 | ||
|
| ||||
| Human cell |
Glioblastoma | RNA pol I, II, III |
38 | |
| Cellular morphology | ||||
| RNA pol II, III | ||||
| RNAi | Ubiquitous |
|
||
| C. elegans | Lipid homeostasis | 16 | ||
|
|
||||
| Intestine | Reproduction | |||
|
|
||||
| Drosophila | Fat body | Organismal growth | 15, 42 | |
|
| ||||
| Knockout | Mouse | Ubiquitous | Food intake Body weight Reproduction |
41 |