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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Biochim Biophys Acta. 2015 Jun 10;1852(9):1805–1809. doi: 10.1016/j.bbadis.2015.05.016

Figure 1.

Figure 1

The map of human mtDNA. The orientation is according to the revised Cambridge Reference Sequence (rCRS, GenBank NC_012920.1). Black bent arrows designate origins and direction of new H-strand (OH) and L-strand (OL) synthesis during replication (or, conversely, origins of L-strand and H-strand replication), respectively. Red bent arrows designate mitochondrial promoters that transcribe either H-strand (HSP1 and HSP2) or L-strand (LSP), respectively. Brown arrows: MT-ND1-MT-ND6, NADH dehydrogenase subunits 1 through 6. Blue arrows: MTCO1-MTCO3, cytochrome oxidase subunits 1 through 3. Black arrows: MTATP6 and MT-ATP8, subunits 6 and 8 of the mitochondrial ATPase, Red arrow: MT-CYB, cytochrome b. tRNAs are designated by green letters using single-letter codes for corresponding amino acids.