Table 1.
Top three networks identified in erlotinib‐resistant HNSCC cell lines.
| Network rank | ||||
|---|---|---|---|---|
| #1 | #2 | #3 | ||
| FaDu | Network | Beta‐catenin, Tcf(Lef), TCF7L2 (TCF4), Lef‐1, Axin | CREB1, G‐protein alpha‐s, CREM (activators), NF‐AT1(NFATC2), PKA‐reg (cAMP‐dependent) | TRAF6, NF‐kB, IKK‐gamma, RIPK1, TAK1(MAP3K7) |
| GO Processes | canonical Wnt signaling pathway, Wnt signaling pathway, regulation of cell differentiation, regulation of developmental process epithelium development | glucose metabolic process, hexose metabolic process, monosaccharide metabolic process, response to oxygen‐containing compound, response to endogenous stimulus | regulation of I‐kappaB kinase/NF‐kappaB signaling, toll‐like receptor 4 signaling pathway, toll‐like receptor signaling pathway, positive regulation of I‐kappaB kinase/NF‐kappaB signaling, positive regulation of NF‐kappaB transcription factor activity | |
| p‐Value | 1.19E‐29 | 1.370E‐18 | 8.850E‐28 | |
| zScore | 11.62 | 9.46 | 11.51 | |
| gScore | 152.87 | 35.71 | 26.51 | |
| Cal‐27 | Network | Androgen receptor, WNT, Frizzled, p21, LRP5 | NF‐kB, TLR4, I‐kB, IL‐1 beta, TIRAP (Mal) | SARS2, SEZ6L2, ANTXR2, TCP1‐zeta‐2, ACSL5 |
| GO Processes | positive regulation of macromolecule metabolic process, regulation of cell cycle, positive regulation of metabolic process, Wnt signaling pathway, organ development | MyD88‐dependent toll‐like receptor signaling pathway, toll‐like receptor signaling pathway, positive regulation of defense response, toll‐like receptor TLR6:TLR2 signaling pathway, toll‐like receptor TLR1:TLR2 signaling pathway | G‐protein coupled purinergic nucleotide receptor signaling pathway, purinergic nucleotide receptor signaling pathway, G‐protein coupled purinergic receptor signaling pathway, purinergic receptor signaling pathway, regulation of inhibitory postsynaptic membrane potential | |
| p‐Value | 6.81E‐09 | 1.02E‐11 | 5.12E‐48 | |
| zScore | 9.35 | 11.75 | 32.64 | |
| gScore | 221.85 | 151.75 | 32.64 | |
| SQ20B | Network | Beta‐catenin, Tcf(Lef), TCF7L2 (TCF4), Lef‐1, Axin | CREB1, G‐protein alpha‐s, CREM (activators), NF‐AT1(NFATC2), PKA‐reg (cAMP‐dependent) | TRAF6, NF‐kB, IKK‐gamma, RIPK1, TAK1(MAP3K7) |
| GO Processes | canonical Wnt signaling pathway, Wnt signaling pathway, regulation of cell differentiation, regulation of developmental process, epithelium development | glucose metabolic process, hexose metabolic process, monosaccharide metabolic process, response to oxygen‐containing compound, response to endogenous stimulus | regulation of I‐kappaB kinase/NF‐kappaB signaling, toll‐like receptor 4 signaling pathway, toll‐like receptor signaling pathway, positive regulation of I‐kappaB kinase/NF‐kappaB signaling, positive regulation of NF‐kappaB transcription factor activity | |
| p‐Value | 1.190E‐29 | 1.370E‐18 | 8.850E‐28 | |
| zScore | 11.62 | 9.46 | 11.51 | |
| gScore | 152.87 | 35.71 | 26.51 | |
| SCC‐25 | Network | ESR1 (nuclear), TPL2(MAP3K8), IL‐6, PKC‐delta, HMGB1 | GLCCI1, MBLAC2, NSL1, KPR2, Cathepsin F | IFT52, FLJ32115, SDOS, DGCR2, C1orf74 |
| GO Processes | toll‐like receptor TLR6:TLR2 signaling pathway, toll‐like receptor TLR1:TLR2 signaling pathway, toll‐like receptor 2 signaling pathway, positive regulation of defense response, positive regulation of response to stimulus | succinate metabolic process, glycine decarboxylation via glycine cleavage system, single‐organism metabolic process, succinyl‐CoA metabolic process, glycine catabolic process | cellular glucuronidation, uronic acid metabolic process, glucuronate metabolic process, flavonoid glucuronidation, flavonoid biosynthetic process | |
| p‐Value | 8.33E‐05 | 6.83E‐37 | 8.97E‐36 | |
| zScore | 5.87 | 29.51 | 28.54 | |
| gScore | 649.62 | 29.51 | 28.54 | |