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. 2015 Aug 3;210(3):401–417. doi: 10.1083/jcb.201506110

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© 2015 Ganguly et al.

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Figure 9. — Model of axonal F-actin. (A) Interpretative illustration derived from data. Actin monomers nucleate and polymerize at discrete microscopic zones in axons (light gray vertical bar). The hotspots are likely sites where actin nucleates on stationary endosomes. (B) Working model showing both subplasmalemmal actin rings and intra-axonal actin filaments. Note that actin monomers nucleate and extend polymers along the long axis of the axon, generating a steady-state scenario where actin is equilibrated along the axon, allowing spatiotemporal control throughout the long processes, and facilitating delivery into presynaptic boutons.