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Model for Lrrk regulation of GOP dynamics. In the absence of Lrrk, GOPs are transported by dynein toward minus ends of microtubules (left). Lrrk binds to and phosphorylates Lva, disrupting the association of GOPs to dynein, leaving GOPs static (top right). Lrrk2 mutation G2019S promotes GOP movement toward cell bodies, a process that might rely on kinesin-based transport (bottom right).
