Table 1. Comparison of previously reported calcitonin-negative neuroendocrine tumors of thyroid with presented case.
| Author | Immunohistochemistry | Nomenclature | Treatment |
|---|---|---|---|
| Eusebi et al. (2 cases) (10) | Chromogranin A + | Calcitonin free oat cell carcinoma | Total thyroidectomy (1 case) |
| Synaptophysin + | |||
| Calcitonin – | Autopsy result (1 case) | ||
| Thyroglobulin – | |||
| Tumor cells had small cell characteristics | |||
| Schmid et al. 4 cases) (6) | Chromogranin A + | Atypical medullary thyroid carcinoma | Surgery (presumably total thyroidectomy) |
| Synaptophysin + | |||
| Amyloid - | |||
| Thyroglobulin - | |||
| Calcitonin - (3 cases) | |||
| Calcitonin focally + (1 case) | |||
| CGRP- (2 cases) | |||
| CGRP focally + (2 cases) | |||
| Wang et al. (5) | Chromogranin A + | Calcitonin negative medullary thyroid cancer | Surgery (total thyroidectomy + radical neck dissection) |
| TTF-1 + | |||
| Calcitonin minimally + | |||
| CEA + | |||
| Thyroglobulin - | |||
| PTH - | |||
| Amyloid (with Congo red) - | |||
| Chernyavsky et al. (1) | Chromogranin A weakly + | Calcitonin negative neuroendocrine tumor of thyroid | Surgery (total thyroidectomy) |
| Synaptophysin + | |||
| Thyroglobulin + (tumor was derived from follicular cells) | |||
| Neuron specific enolase + | |||
| Calcitonin - | |||
| Nakazawa et al. (11) | Chromogranin A + | ’C-cell derived calcitonin free neuroendocrine carcinoma of thyroid | Surgery (left hemithyroidectomy) |
| Synaptophysin + | |||
| Calcitonin - | |||
| Thyroglobulin – | |||
| Calcitonin gene related peptide + (diagnostic property of tumor) | |||
| Ismi et al.* | Chromogranin A + | Calcitonin negative neuroendocrine tumor of thyroid | Chemotherapy (unresectable tumor with distant metastases) |
| Synaptophysin + | |||
| Calcitonin - | |||
| Thyroglobulin – | |||
| TTF-1 - | |||
| S 100 - | |||
| CEA - |
*, presented case.