Figure 2.

Quantitative Lipidomics of Nine Stable shRNA Cell Lines Targeting Sphingolipid Metabolism Reveals Strongly Altered Lipid States

(A) Lipidomics analysis of nine loss-of-function cell lines. Values are shown as log₂ fold-change relative to sh:GFP. Each dot represents a lipid species, color coded per lipid class. Dot size indicates significance. Lipidomics data are combined of three independent experiments and represented as mean.

(B) Hierarchical clustering of average log₂ fold-change lipid levels per lipid class and cell line. Lipidomics data are combined of three independent experiments and represented as mean. ^∗p < 0.05.

See also Figure S2 and Table S2.