Table 1.
Phenotypic characteristics of Lewis and LPK rats.
| Parametern | Lewis/8 | LPK/6 | p-value |
|---|---|---|---|
| Body weight (g) | 332 ± 8 | 254 ± 8 | < 0.0001 |
| Water intake (ml/24 h) | 25 ± 1 | 50 ± 3 | < 0.0001 |
| Urine output (ml/24 h) | 11 ± 1 | 51 ± 3 | < 0.0001 |
| UPro (g/L) | 0.05 ± 0.01 | 0.89 ± 0.41 | < 0.0001 |
| UCr (g/L) | 1.2 ± 0.2 | 0.2 ± 0.1 | 0.0006 |
| UPC | 0.06 ± 0.02 | 5.9 ± 3.2 | < 0.0001 |
| MAP (mmHg) | 97 ± 2 | 151 ± 8 | < 0.0001 |
| RSNA (μV) | 0.6 ± 0.1 | 1.2 ± 0.1 | 0.0190 |
LPK, Lewis Polycystic Kidney; UPro, urinary total protein; UCr, urinary creatinine; UPC, urinary protein-to-creatinine ratio; RSNA, renal sympathetic nerve activity and MAP, mean arterial pressure. Results are expressed as mean ± SEM. In the Lewis, UPC was not calculated in 3/9 animals due to lack of detectable protein levels in the urine. Accordingly, only 6 Lewis animals were used to compare mean values of UPC. p-values determined using a two-tailed Student's t-test. (n) values denoted in subscript and represent the minimum number in each group.