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. 2015 Aug 4;9:288. doi: 10.3389/fncel.2015.00288

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Copyright © 2015 Imayoshi, Ishidate and Kageyama.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression dynamics of bHLH factors in multipotency and cell fate choice. In multipotent NSCs, the levels of Hes1 and Ascl1 oscillate with periods of 2–3 h, while that of Olig2 oscillates with a period of 5–8 h. By contrast, during cell fate choice, one of the bHLH factors is expressed in a sustained manner, while the others are repressed.