FIGURE 3.

Infection-regulated genes in predicted host and fungi interactors. (A) Differentially expressed genes in murine innate immune cells 30, 60, 90, and 120 min post-infection with Candida albicans cells. Bars above the x-axis show the number of significantly upregulated genes, while bars below show the significantly downregulated genes. (B) Differentially expressed genes in C. albicans 30, 60, 90, and 120 min post-infection of murine innate immune cells. (C) Fraction of significantly deregulated genes in the sets of protein-coding genes, the primary inferred, the localization-filtered, and the functionally refined interactors of mouse. (D) Fraction of significantly deregulated genes in the sets of protein-coding genes, the primary inferred, the localization-filtered, and the biological process refined interactors of C. albicans. A test for enrichment of infection-regulated genes in the interactor sets after the primary inference, localization, and functional refinement step (Fisher exact test, ***p< 0.001).