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. 2015 Aug 4;6:764. doi: 10.3389/fmicb.2015.00764

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Copyright © 2015 Remmele, Luther, Balkenhol, Dandekar, Müller and Dittrich.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Host–pathogen PPI subnetwork between H. sapiens and A. fumigatus. This subnetwork comprises pathogenicity-associated (HPIDB) host interactors annotated as “symbiosis, encompassing mutualism through parasitism” and pathogen interactors annotated as “pathogenesis.” Blue nodes represent host interactors and green nodes fungal interactors. Nodes with a red border showed evidence for virulence contribution (PHIDIAS, PHI-base, and AspGD) or other host–pathogen interactions (HPIDB). Interactions highlighted by red edges were described in more detail.