Table 2.

Numbers of genes in the primary predicted host–fungal PPI networks belonging to the biological process GO filter terms.

(A) Filter terms for host side
GO slim biological process terms	Number of genes in H. sapiens	Number of genes in M. musculus
Signal transduction	951	602
Immune system process	491	255
Symbiosis, encompassing mutualism through parasitism	260	0
Cell adhesion	151	127
Circulatory system process	50	53
Only Other Slim BP annotations	1,246	878
No GOSlim BP annotation	0	0
(B) Filter terms for fungi side
GO slim biological process terms	Number of genes in A. fumigatus	Number of genes in C. albicans
Pathogenesis	30	33
Cell adhesion	10	24
Biofilm formation	0	32
Interspecies interaction between organisms	0	30
Growth of unicellular organism as a thread of attached cells	0	2
Only Other Slim BP annotations	330	244
No GOSlim BP annotation	0	0
(C) Sizes of host-fungi networks after functional refinement
Host species	Pathogen species	Number of host–pathogen interactions	Number of host interactors	Number of pathogen interactors
H. sapiens	A. fumigatus	1,137 (6.4%)	607 (25.4%)	33 (9.1%)
H. sapiens	C. albicans	3,025 (19.7%)	840 (39.6%)	57 (18.9%)
M. musculus	A. fumigatus	590 (6.4%)	355 (22.6%)	26 (7.7%)
M. musculus	C. albicans	1,462 (18.2%)	461 (33.5%)	41 (14.5%)