Table 2.

Targets validated by Tet-mediated control of Mtb gene expression in vivo.

Gene	Protein	Function	Phase of infection	Reference
prcBA	Proteasome α and β subunits	ATP-dependent degradation of damaged proteins	Chronic	Gandotra et al. (2007), Blumenthal et al. (2010)
pckA	Phosphoenolpyruvate carboxykinase	Catalyzes the first committed step in gluconeogenesis	Acute and chronic	Marrero et al. (2010)
icl1	Isocitrate lyase	Catalyzes the conversion of isocitrate to glyoxylate and succinate in the first step of the glyoxylate shunt	Acute and chronic	Blumenthal et al. (2010)
Rv3671c	Serine protease	Role in protection from oxidative stress and acidification	Chronic	Blumenthal et al. (2010)
pptT	4′-phosphopantetheinyl transferase	Transfer of 4′-phosphopantetheine group from Coenzyme A (CoA) to acyl carrier proteins	Acute and chronic	Leblanc et al. (2012)
fba	Fructose-1,6-bisphosphate aldolase (FBA)	Reversible cleavage of fructose-1,6-bisphosphate to yield dihydroxyacetone phosphate and glyceraldehyde 3-phosphate in glycolysis and gluconeogenesis	Acute and chronic	Puckett et al. (2014)
pimA	Phosphatidyl-myo-inositol mannosyltransferase	Transfer of mannosyl residue from GDP-Man to phosphatidyl-myo-innositol	Acute and chronic	Boldrin et al. (2014)
relA	GTP-pyrophosphokinase	Synthesis of (p)ppGpp	Acute and chronic	Weiss and Stallings (2013)
carD	Transcriptional regulator	Regulates transcription initiation Srivastava et al. (2013)	Acute and chronic	Stallings et al. (2009)
bioA	7,8-diaminopelargonic acid synthase	Catalyzes the antepenultimate step in biotin biosynthesis	Acute and chronic	Woong Park et al. (2011)