Table 3.
Statistical information of significant clusters highlighted when comparing the BOLD response between the spontaneous and directed use of learning strategies during word list encoding compared to fixation baseline.
| Contrast | Region | Side | MNI coordinates | Size | Cluster p-values | |||
|---|---|---|---|---|---|---|---|---|
| x | y | z | ||||||
| Directed > spontaneous | ||||||||
| controls | VLPFC | 2131 | < 0.0001 | |||||
| Inferior frontal gyrus (BA 44) | L | −42 | 10 | 32 | 4.6 | |||
| Inferior frontal gyrus (BA 45) | L | −46 | 24 | 24 | 4.25 | |||
| midDLPFC | 1021 | < 0.0001 | ||||||
| Middle frontal gyrus (BA 46) | L | −36 | 0 | 54 | 4.04 | |||
| Precentral gyrus (BA 6) | L | −42 | 0 | 32 | 4.17 | |||
| Posterior parietal cortex | 977 | < 0.0001 | ||||||
| Intraparietal sulcus (BA 7) | L | −24 | −70 | 48 | 4.27 | |||
| Angular gyrus (BA 40) | L | −34 | −58 | 40 | 3.58 | |||
| Pre−SMA | 545 | 0.0032 | ||||||
| Superior frontal gyrus (BA 6) | L | −6 | 2 | 58 | 4.66 | |||
| Cingulate gyrus (BA 32) | R | 6 | 20 | 36 | 3.86 | |||
| Cerebelum | L | −40 | −76 | −26 | 4.27 | 412 | 0.0021 | |
| MCI | DLPFC | 1416 | < 0.0001 | |||||
| Middle frontal gyrus (BA 9) | L | −42 | 8 | 50 | 3.95 | |||
| Middle frontal gyrus (BA 46) | L | −44 | 44 | 12 | 3.82 | |||
| Inferior frontal gyrus (BA 47) | L | −46 | 38 | 6 | 3.44 | |||
| Inferior frontal gyrus (BA 47) | L | −52 | 18 | 0 | 3.71 | |||
| Left temporoparietal cortex | 1003 | < 0.0001 | ||||||
| Intraparietal sulcus superior | L | −28 | −62 | 32 | 4.56 | |||
| Angular gyrus (BA 39) | L | −34 | −70 | 38 | 4.45 | |||
| Superior temporal gyrus (BA 22) | L | −42 | −50 | 22 | 3.27 | |||
| Right temporo−parietal | 654 | 0.00015 | ||||||
| Supramarginal gyrus (BA 40) | R | 42 | −52 | 32 | 3.51 | |||
| Middle temporal gyrus (BA 39) | R | 40 | −62 | 32 | 3.48 | |||
| Precuneus(BA 7) | R | 32 | −62 | 42 | 3.44 | |||
| Directed < spontaneous | ||||||||
| controls | Precuneus/Posterior cingulate | 1894 | < 0.0001 | |||||
| Posterior cingulate (BA 30) | L | −16 | −66 | 12 | 3.97 | |||
| Precuneus (BA 7) | L | 0 | −54 | 46 | 3.83 | |||
| mPFC | 1710 | < 0.0001 | ||||||
| Superior frontal gyrus (BA 10) | R | 12 | 54 | −4 | 4.37 | |||
| Anterior cingulate gyrus (BA 24) | R | 0 | 36 | 8 | 3.77 | |||
| Inferior temporal | 896 | < 0.0001 | ||||||
| Inferior parietal lobule (BA 39) | R | 50 | −48 | 24 | 4.16 | |||
| Supramarginal gyrus (BA 40) | R | 60 | −50 | 30 | 3.69 | |||
| Middle temporal gyrus (BA 21) | R | 52 | −56 | 6 | 3.34 | |||
| Superior temporal gyrus (BA 22) | R | 52 | −44 | 10 | 3.26 | |||
| Superior temporal | 619 | 0.0012 | ||||||
| Middle temporal gyrus (BA 21) | R | 64 | −6 | −16 | 3.74 | |||
| Superior temporal gyrus (BA 22) | R | 56 | −26 | 8 | 3.72 | |||
| Superior frontal | 528 | 0.004 | ||||||
| Superior frontal gyrus (BA 9) | R | 24 | 40 | 46 | 3.77 | |||
| Middle frontal gyrus (BA 46) | R | 26 | 46 | 30 | 3.35 | |||
| OFC | 421 | 0.0171 | ||||||
| Middle orbital gyrus (BA11) | R | 18 | 16 | −22 | 3.5 | |||
| Rectus gyrus (BA 11) | L | −6 | 6 | −22 | 3.1 | |||
| MCI | Parieto−occipital | 710 | < 0.0001 | |||||
| Lyngual gyrus (BA 18) | L | −2 | −100 | −4 | 3.65 | |||
| Cuneus (BA 17) | L | −6 | −98 | 8 | 3.6 | |||
| Cuneus (BA 17) | R | 6 | −92 | 26 | 3.38 | |||