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. 2015 Aug 4;5:12853. doi: 10.1038/srep12853

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Copyright © 2015, Macmillan Publishers Limited

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(A) The lumbar vertebral bodies (L5) of all mice were scanned with a high-resolution micro-CT. (B–F) Calculation of the microstructural indices was performed for the micro-CT data as described in the Methods section. Microstructural indices include bone volume/tissue volume (BV/TV), bone surface/bone volume (BS/BV), trabecular separation (Tb.Sp.), trabecular thickness (Tb.Th.), and trabecular number (Tb.N.) (*P < 0.05; **P < 0.01). (G) The vertebral bodies of L3-L5 were fixed in 4% paraformaldehyde, decalcified, embedded, and sectioned as described in the Methods section. Sections of vertebral bodies were stained with H&E (40×) and TRAP (200×). (H) BV/TV was measured in sections stained with H&E (**P < 0.01). (I,J) The percentage of osteoclast surface per bone surface (OcS/BS%) and the number of osteoclasts per field of tissue in sections stained by TRAP in 200× magnification were analysed (**P < 0.01).