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. 2015 Aug 4;9:298. doi: 10.3389/fncel.2015.00298

FIGURE 2.

FIGURE 2

Methylcobalamin reduces the activity of Erk1/2 in SCs. (A,C) SCs were cultured with MeCbl at a concentration of 1 nM–100 μM for 1 h in the growth medium. Erk1/2 (A) and Akt (C) activities were detected by western blotting. The quantification of the normalized density of Erk1/2 (A) and Akt (C) is shown. (B,D) SCs were cultured with MeCbl at a concentration of 100 μM for 3 h in the growth medium. Erk1/2 (B) and Akt (D) activities were detected by western blotting. The quantification of the normalized density of Erk1/2 (B) and Akt (D) is shown. Values are means ± SEM of five independent experiments. *p < 0.05 compared with the control group.