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. 2015 Aug 4;9:298. doi: 10.3389/fncel.2015.00298

FIGURE 6.

FIGURE 6

Methylcobalamin promotes remyelination after LPC-induced sciatic nerve demyelination in vivo. (A–C) Fluorescence micrographs of cross-sectional slices of sciatic nerves labeled for MBP (red), NF200 (green), and DAPI (blue) 7 days after the LPC [b; LPC (+)] or saline [c; LPC (-)] injection. Images taken at a higher magnification are shown in the insets. (D) Quantification of MBP-positive axons per total axons (NF200-positive axons) 7 days after the LPC or saline injection. (E–L) MeCbl or saline was administered systemically 7 days after the injection. Fluorescence micrographs of cross-sectional slices of sciatic nerves labeled for MBP red (E–L), NF200 green (F,H,J,L), and DAPI blue (F,H,J,L) 7 days after the administration of MeCbl or saline. Images taken at a higher magnification are shown in the insets. (M) Quantification of MBP-positive axons per total axons (NF200-positive axons) 7 days after the administration of MeCbl or saline. ***p < 0.001. Values are means ± SEM of three independent experiments.