Table 1.
Control | Ivabradine | Ivabradine | Ivabradine | |
---|---|---|---|---|
3 μM | 10 μM | 30 μM | ||
(n = 9) | (n = 9) | (n = 9) | ||
V1/2 activation (mV) | −68 ± 4 | −70 ± 4 | −74 ± 4 * | −77 ± 5 * |
(p = 0.07) | (p = 0.02) | (p = 0.04) | ||
Max τact | 157 ± 11 | 120 ± 17 | 106 ± 17 * | 80 ± 13 * |
(ms) | (P = 0.5) | (P = 0.05) | (P = 0.02) | |
If density (pA/pF) | 4.5 ± 0.7 | 2.1 ± 0.3 * | 1.6 ± 0.2 * | 1.1 ± 0.2 *,# |
(V = control V1/2 activation) | (P = 0.04) | (P = 0.008) | (0.004) | |
If (pA/pF) (V = MDP) | 3 ± 0.43 | 2 ± 0.3 * | 1.5 ± 0.2 * | 1.3 ± 0.2 * |
(P = 0.045) | (P = 0.04) | (P = 0.01) |