Figure 2. Plots of inter-residue contacts (ICs) vs experimentally determined binding affinities (ΔGs) of protein–protein complexes.
(A) Full dataset (122 complexes), (B) reliable experimental methods only (stopped-flow, surface plasmon resonance, spectroscopy, isothermal titration calorimetry) (81 complexes), and (C) non-reliable experimental methods (inhibition assay and fluorescence) (36 complexes). The trend line and corresponding Pearson correlation coefficients and p-values (ρ) are reported in each plot; binding affinities are reported as absolute values.