Figure 4. Comparison of the performance of our ICs/NIS-based model (Model 6, Equation 2) with other predictor models reported by Moal et al. (2011) and the CCHarPPI (Moal et al., 2015a, b) webserver.
The performance is expressed as Pearson's Correlation coefficient between experimental and predicted binding affinities. Predictions were made on the common set of 79 complexes between our cleaned dataset, the data tested by Moal et al. (2011) and the CCHarPPI (Moal et al., 2015a, b) pre-calculated data. Correlations for the entire set and the rigid (43) and flexible (36) complexes are reported as absolute values for easier comparison (methods marked with asterisk showed original negative correlations).