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. 2015 Jul 23;2015(7):CD000371. doi: 10.1002/14651858.CD000371.pub6
Date Event Description
27 July 2015 Amended We added an external source of support, the Evidence and Programme Guidance Unit, Department of Nutrition for Health and Development, World Health Organization (WHO), to the Acknowledgements and Sources of support sections.
8 July 2015 New citation required but conclusions have not changed A new search was conducted and new trials added. We also responded to feedback.
26 February 2015 New search has been performed

  1. We added four new trials: two in the category children infected and two in an endemic area.

  2. The results from the Awasthi 2013 (Cluster) (DEVTA) trial were added.

  3. We used the replication (Aiken 2015) to correct the errors in the primary publication by Miguel 2004 (Cluster)); and used the statistical replication (Davey 2015) to inform risk of bias and interpretation.

  4. We took account of comments and criticisms from Miguel and Kremer in the analysis. This included a proposal to use single set of follow‐up outcomes. After performing new analyses in this review, we found that there was no evidence that the intervention effect varied with length of follow‐up, and therefore consolidated the analysis of (ie < 1 year and > 1 year) in the previous Cochrane Review (Taylor‐Robinson 2012) into one set.

  5. We changed the classification of Stephenson 1989 and Stephenson 1993. Previously these trials were in the "all children in an endemic area" category, whereas now they are classified in the "children with infection". This decision was based on reviewing the trials with parasitologists and examining the prevalence and intensity of the infection where clearly the whole community was heavily infected.

  6. We noticed that the trial Adams 1994 was actually a sub‐trial of Stephenson 1993 and therefore merged with Stephenson 1993 (the full citation to Adams 1994 can be found in Stephenson 1993). The total number of trials in the review has changed accordingly. The data previously contributed to the review by Adams 1994 has been removed, since more complete outcome data for the whole Stephenson 1993 trial is reported in the other articles.

  7. We adjusted the 'Summary of findings' tables, review text, and conclusions in the light of these changes.
10 October 2012 New citation required but conclusions have not changed We updated the 'Summary of findings' tables, updated the abstract, and made minor corrections.
10 October 2012 New search has been performed In September 2012, we identified a minor data entry error with a haemoglobin value, which we corrected.
We also received feedback on the GRADE assessments. This led to changes in the assessment of the quality of the evidence for several outcomes. Most changes were towards higher quality evidence. We refined the table by adding additional footnotes to clarify the classification. The specific changes were:

  • For single dose weight screened, GRADE moved from moderate to low;

  • For single dose haemoglobin GRADE moved from low to moderate, after data entry corrected; and for formal tests, GRADE moved from very low to low;

  • For multiple dose (< 1 year), formal tests and schooling moved from very low to low, following upgrading of study quality;

  • For multiple doses (> 1 year), weight and haemoglobin moved from very low to low, following upgrading of study quality; and cognition moved from very low to low.


We adjusted the wording in the abstract to take these changes into account.
31 May 2012 New search has been performed Substantive update:

  1. We added a logic framework to the background.

  2. We replaced Awasthi 1995 (unpublished data) with the published data (Awasthi 1995 (Cluster)). We received clarification on methods and results from Miguel and Kremer and included this study in the review (Miguel 2004 (Cluster)). Also, we tried to include the Awasthi 2013 (Cluster) completed in 2006 but were unable to as it remains unpublished as of May 2012.

  3. We added haemoglobin as a primary outcome and we added all trials measuring haemoglobin. We merged end values and change values to simplify the review. We reanalysed the school attendance data. In addition, we brought the sensitivity analysis in line with current best practice (by only including trials with evidence of allocation concealment).

  4. We added 'Summary of findings' tables. We adjusted the wording in line with our policy of using standard words to correspond to quality of the evidence.

  5. In the light of these changes, we rewrote the review entirely.
31 May 2012 New citation required but conclusions have not changed We updated the review and added new studies.
7 May 2008 Amended There are two alterations to the review:

  1. We have corrected an error in the discussion. The sentence that read "There was a weight gain of 2.413 kg in the treatment parishes and 2.474 kg in the control parishes at an unspecified follow‐up point." now reads "There was a weight gain of 2.413 kg in the treatment parishes and 2.259 kg in the control parishes at an unspecified follow‐up point."

  2. We have detailed our correspondence to date with Michael Kremer and Edward Miguel in the discussion.
12 August 2007 New citation required and conclusions have changed 2007, Issue 4 (substantive update): author team changed; we modified the review title from the original title of "Anthelmintic drugs for treating worms in children: effects on growth and cognitive performance"; we updated methods, reapplied the inclusion criteria, repeated data extraction, added new trials, and included additional analyses as recommended by policy specialists.
31 March 2000 New citation required and conclusions have changed 2000, Issue 2 (substantive update): we added new trials and updated the review.