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. 2015 Jul 23;2015(7):CD000371. doi: 10.1002/14651858.CD000371.pub6
Methods Quasi‐RCT
Length of follow‐up: 1.75 months (7 weeks)
Participants All children living in endemic area
Number analysed for primary outcome: 64
Age range: 6 to 10 years
Inclusion criteria: boys aged 6 to 10 years attending second grade at 3 primary schools; completed assessment and provided a stool sample; randomized by descending hookworm count (all treated)
Exclusion criteria: none stated
Interventions Single dose vs placebo
  1. Pyrantel pamoate: 10 mg/kg;

  2. Placebo.

Outcomes
  1. Mean weight post‐treatment;

  2. Appetite: consumption test (mL porridge) and self assessment.


Not included in review: egg counts arithmetic and geometric means (Kato‐Katz); weight‐for‐age (NCHS reference)
Notes Location: Indonesia
Community category: 1
Large drops in geometric mean egg counts in placebo noted
Source of funding not reported.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Randomized: "Randomly assigned" by descending A. lubricoides egg count"
Allocation concealment (selection bias) Unclear risk No details reported.
Blinding (performance bias and detection bias) All outcomes Unclear risk "Double‐blind". Participants blinded both placebo and treatment identical round white tablets, no information about provider and assessor blinding.
Incomplete outcome data (attrition bias) All outcomes Low risk 85% (64/75) of randomized participants were evaluated. Reasons for loss to follow‐up included: moved away, refused to be examined, did not return a stool sample, absent during examination. Not clear how many lost from each treatment group. Inclusion of all randomized participants (number evaluable/number randomized): 85% (64/75).
Selective reporting (reporting bias) Low risk All stated outcomes reported.
Other bias Low risk No obvious other source of bias.