Michaelsen 1985

Methods	RCT Length of follow‐up: 5 months
Participants	All children living in endemic area Number analysed for primary outcome: 121 for nutritional outcomes Age range: 5 to 14 years Inclusion criteria: children from a school identified as having high prevalence of hookworm on the basis of a previous survey Exclusion criteria: children with height above 137 cm girls and 145 cm for boys since these were the upper limits in the reference ranges
Interventions	Single dose vs placebo Tetrachloroethylene: 0.1 mL/kg (max 5 mL dose); Placebo: children's cough medicine.
Outcomes	Measured: Stool: prevalence in subgroup; Haemoglobin; Weight; Height; Weight‐for‐height (WHO reference median 1983). Reported: Stool prevalence (graph) with 95% CIs; Haemoglobin mean and difference (no SD); Weight‐for‐height %, mean and difference (no SD).
Notes	Location: Botswana Community category: 1 Source of funding not reported.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	"Random sample of half the children" were give the treatment and the remaining the placebo; no further details reported.
Allocation concealment (selection bias)	Unclear risk	No details reported.
Blinding (performance bias and detection bias) All outcomes	Unclear risk	No details reported.
Incomplete outcome data (attrition bias) All outcomes	High risk	53% (121/228) of randomized participants were evaluated. Inclusion of all randomized participants (number evaluable/number randomized): 53% (121/228).
Selective reporting (reporting bias)	Low risk	Pre‐specfied outcomes reported.
Other bias	Low risk	No obvious other sources of bias.