Simeon 1995

Methods	RCT Length of follow‐up: 6.5 months (26 weeks)
Participants	Infected children identified by screening Number analysed for primary outcome: 392 Age range: 6 to 12 years Inclusion criteria: children in grades 2 to 5 of 14 schools in Jamaica with intensities of Trichura > 1200 eggs/g Exclusion criteria: children with mental handicaps identified by their teachers
Interventions	Multiple doses vs placebo Albendazole: 800 mg (400 mg in each of 2 days), repeated at 3 months and 6 months; Identical placebo.
Outcomes	1. Main trial (264 children) Wide range achievement test: reading, arithmetic, and spelling subtests; school attendance from children with class registers pre‐ and post‐intervention, height‐for‐age z‐score, body mass index pre‐ and post‐intervention 2. Subgroup 1 (189 infected children from original population) Digit span; verbal fluency test; visual search; number choice; French vocabulary learning 3. Subgroup 2 (97 children from grade 5) French learning; digit spans (forward and backward); Corsi block span; verbal fluency; picture search; silly sentences Other outcomes measured but not reported: stool at baseline and at 8 weeks after second treatment round (Kato): prevalence and intensity, weight, height, z‐scores (NCHS standard)
Notes	Location: Jamaica Community category: 1 Source of funding: grant from the James S. McDonnell Foundation.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Random‐numbers table.
Allocation concealment (selection bias)	Unclear risk	No details reported.
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Paricipants blinded; unclear whether assessors were blinded.
Incomplete outcome data (attrition bias) All outcomes	Low risk	96% (392/407) of randomized participants were evaluated. Inclusion of all randomized participants (number evaluable/number randomized): 96% (392/407).
Selective reporting (reporting bias)	Low risk	All stated outcomes reported.
Other bias	Low risk	No obvious other source of bias.