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. 2015 Jul 23;2015(7):CD000371. doi: 10.1002/14651858.CD000371.pub6
Methods RCTRCT
Length of follow‐up: 6 months
Participants Infected children identified by screening
Number analysed for primary outcome: 194
Age range: 9 to 12 years
Inclusion criteria: children aged 9 to 12 years from 5 primary schools, with at least one type of STH infection.
Exclusion criteria: deworming treatment within 6 months before the current trial.
Interventions Single dose vs placebo
  1. Albendazole: 3 x 400 mg for 3 consecutive days;

  2. Matching placebo.

Outcomes
  1. Physical fitness (10 m shuttle run and VO2 max);

  2. Physical strength (grip strength and standing broad jump test);

  3. Height;

  4. Weight;

  5. Triceps and subscapular skinfold thickness;

  6. Haemoglobin.


Not included in review: parasitological examination.
Notes Location: Bulanghsam township bordering Myanmar, a sub‐division of Menghai county in Xishuangbanna Dai autonomous prefecture, situated in Yunnan province, P.R. China
Community category: N/A
Source of funding: Swiss Tropical and Public Health Institute in Basel, Switzerland and the National Institute of Parasitic Diseases, Chinese Center of Diseases Control and Prevention in Shanghai, P.R. China.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk "The treatment allocation sequence was generated by a statistician using block randomization with randomly varying block sizes of 2, 4, and 6."
Allocation concealment (selection bias) Low risk "Albendazole and placebo tablets were packaged by staff not involved in the field work into sealed envelopes marked with unique identifiers."
Blinding (performance bias and detection bias) All outcomes Unclear risk Participants and personnel blinded.
Not reported whether the assessors for height and weight were blinded.
Incomplete outcome data (attrition bias) All outcomes Low risk Inclusion of all randomized participants (number evaluable/number randomized): 92% (194/211).
Selective reporting (reporting bias) Low risk All stated outcomes reported.
Other bias Low risk No other obvious risk of bias.

CI: confidence interval; Community category: a measure of the prevalence and intensity of infection (see Table 11); NCHS: National Center for Health Statistics; SD: standard deviation; SEM: standard error of the mean.