Figure 1. Schematic illustration of virus infection and TGFβ3 treatment on the palatal shelves organ culture.
Palatal shelves were dissected from E13.5 C57BL/6 mouse embryos and cultured for 3 hours. The palatal shelves were then infected with lentivirus, adenovirus, or treated with 20 ng/ml TGFβ3 for indicated time interval. Then the palatal shelves were harvested for RNA extraction or fixed with 4% PFA or had a change of medium and then were cultured for another 6, 12, 18, or 24 hours, after which they were fixed with 4% PFA.