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. 2015 Aug 4;6:159. doi: 10.3389/fphar.2015.00159

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Copyright © 2015 Kono, Shimada, Yamamoto, Kaneko, Oomiya, Kubota, Kase, Lee and Uezono.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hypotheses on synergism of TU-100 compounds on colonic motility. (A) Two-pore-domain potassium channels (i.e., KCNKs family channels) are expressed in many types of excitable cells throughout the body and have been implicated in various cellular functions, including the maintenance of the resting potential and regulation of excitability. Low doses of ginger compounds cannot evoke action potentials. (B) One of compounds of daikenchuto, hydroxy-α-sanshool, acts as a blocker of two-pore-domain potassium leak channels (KCNK3 and KCNK9) and alters the excitability of a cell via voltage-activated cation channels. Low doses of ginger compounds can evoke action potentials.