Skip to main content
. 2015 Aug 4;6:755. doi: 10.3389/fmicb.2015.00755

Table 2.

Studies using filamentous phage as an immunogenic carrier for peptide B-cell epitopes.

Antigen Species Epitope type(s) Display format(s) Ab response against peptide Ab response against native protein Reference(s)
Alzheimer’s disease β-amyloid fibrils Mouse (BALB/c, APP transgenic), Guinea pig Linear pVIII hybrid,
pIII fully recombinant
+ + Frenkel et al. (2000, 2003), Lavie et al. (2004), Esposito et al. (2008), Tanaka et al. (2011)
Aspergillus fumigatus MIRB Mouse (BALB/c) Linear Chemical conjugate + + Raymond-Bouchard et al. (2012)
Bordetella pertussis toxin Mouse (BALB/c) Discontinuous pVIII hybrid + - Felici et al. (1993)
Candida albicans HSP90 Mouse (C57/BL6, BALB/c) Linear pVIII hybrid + + Yang et al. (2005a), Wang et al. (2006, 2014d)
Chlamydia trachomatis major outer membrane protein Mouse (C57/BL6, BALB/c, CBA/j) Linear pVIII hybrid + + Zhong et al. (1994)
Coronavirus S glycoprotein Mouse (C57/BL6, BALB/c) Linear pVIII hybrid + + Yu et al. (2000)
ERBB2/HER2 Mouse (BALB/c) Linear pVIII hybrid,
pIII fully recombinant
+ + Yip et al. (2001)
Entamoeba histolytica proteophosphoglycan Mouse (BALB/c) Discontinuous pVIII hybrid + + Melzer et al. (2002)
Follicle-stimulating hormone Sheep Linear pVIII hybrid + + Abdennebi et al. (1999)
Foot-and-mouth disease VP1 Guinea pig Linear pVIII hybrid ND + Kim et al. (2004)
Gonadotropin-releasing hormone Mouse (CD-1) Linear Chemical conjugate ND ND Samoylov et al. (2012)
HBV surface antigen Mouse (C57/BL6, BALB/c, B10.M) Linear pVIII hybrid,
pIII fully recombinant
+ + Folgori et al. (1994), Motti et al. (1994), Meola et al. (1995), Delmastro et al. (1997)
HCV core antigen and NS4B protein Mouse (C57/BL6, BALB/c, MF1) Linear pVIII hybrid + ND Prezzi et al. (1996), Delmastro et al. (1997)
HCV E2 protein Mouse (BALB/c) Linear pVIII hybrid + ND Puntoriero et al. (1998)
Helicobacter pyloriUrease B Mouse (BALB/c) Linear pIII fully recombinant + + Li et al. (2010c)
HIV-1 gp120 V3 loop Mouse (BALB/c) Linear pVIII hybrid + + di Marzo Veronese et al. (1994)
HIV-1 gp120 CD4-binding site Mouse (BALB/c) Discontinuous Chemical conjugate + - van Houten et al. (2006)
HIV-1 gp120 and gp41 Mouse (C57/BL6, BALB/c), Rhesus macaque Linear,
Discontinuous
pVIII hybrid,
pIII hybrid,
Chemical conjugate
+ ND Scala et al. (1999), Chen et al. (2001), van Houten et al. (2010)
HIV-1 gag p17 Rabbit Linear pVIII fully recombinant + + Minenkova et al. (1993)
HIV-1 reverse transcriptase Mouse (C57BL/6, HLA-A2 transgenic) Linear pVIII hybrid + ND De Berardinis et al. (1999)
HPV E7 protein Mouse (BALB/c) Linear pVIII hybrid + + Lidqvist et al. (2008)
HSV-2 glycoprotein G Mouse (BALB/c) Linear pVIII hybrid + + Grabowska et al. (2000)
Immunoglobulin E Rabbit Discontinuous pVIII hybrid ND + Rudolf et al. (1998)
Mycoplasma hyopneumoniae unknown proteins Mouse (BALB/cByJ) Linear,
Discontinuous
pIII fully recombinant + + Yang et al. (2005b)
Neisseria meningitidis PorA protein Mouse (BALB/c) Linear pVIII hybrid + + Menendez et al. (2001)
Plasmodium falciparum CSP Mouse (BALB/c, C57/BL10, Swiss, Str/ort), rabbit Linear pVIII hybrid,
pIII fully recombinant
+ ND de la Cruz et al. (1988), Greenwood et al. (1991), Willis et al. (1993)
Plasmodium vivax MSP1 Mouse (C57/BL6, BALB/c, Biozzi) Linear,
Discontinuous
pIII hybrid ND + Demangel et al. (1996)
Rhabdovirus RABVG Mouse (BALB/c) Linear pIII fully recombinant + + Houimel and Dellagi (2009)
RSV glycoprotein G Mouse (BALB/c) Linear pIII fully recombinant + - Bastien et al. (1997)
Schistosoma japonicum unknown protein(s) Mouse (Kunming) Discontinuous pIII fully recombinant + ND
Shigella flexneri LPS Mouse (BALB/c) Discontinuous pVIII hybrid,
Chemical conjugate
+ - van Houten et al. (2010), Henry et al. (2011)
Sperm Mouse (CD-1), Pig Discontinuous pVIII fully recombinant + + Samoylova et al. (2012a,b)
Toxic shock syndrome toxin Mouse (BALB/c) Linear pIII fully recombinant + ND Rubinchik and Chow (2000)