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. 2015 Jul 16;7(1):72. doi: 10.1186/s13073-015-0196-5

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© Abraham et al. 2015

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — ROC curves for classifying all CD cases and controls using different predictors in the North American dataset. GRS14: the published GRS (trained on the UK2 dataset); GRS-imputed: a GRS trained on all European GWA datasets (UK, Dutch, Finnish, Italian), consisting of SNPs and SNP2HLA imputed markers; HLA haplotype risk: a 3-level risk score based on the HLA haplotype status